Crash investigators are at the scene and Dumfries and Galloway Police estimate that the road will remain closed until after midday while they attempt to determine exactly what caused the collision.
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Carlisle have secured their Football League status by beating Plymouth Argyle 2-0 at Brunton Park.
Kerrie brings you Saturday night's forecast
Carlisle are preparing for game that could see them safe from relegation. They welcome Plymouth Argyle to Brunton Park for a 3pm kick-off.