Crash investigators are at the scene and Dumfries and Galloway Police estimate that the road will remain closed until after midday while they attempt to determine exactly what caused the collision.
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Sandy Murray, of Police Scotland, was was giving evidence at the trial of a bus driver who denies killing Ryan Baird by dangerous driving.
34-year-old Christopher Peck was involved in a head-on crash with a drunk driver. His funeral has taken place in his hometown, Workington.
The arrests come weeks after a much-publicised series of appeals to mark the 30th anniversary of the 18-year-old's death.