Crash investigators are at the scene and Dumfries and Galloway Police estimate that the road will remain closed until after midday while they attempt to determine exactly what caused the collision.
More top news
A look ahead at the weekend forecast for the Border region.
After a nine-month re-development, people can now journey on the La'al Ratty railway to the new Ravenglass Railway Museum.
An art exhibition will be taking place this weekend at the Rose Castle, which used to be the private home of the Bishops of Carlisle.