A spokesman for Yes Scotland, the campaign for Scottish independence, said it was "up for the challenge" of convincing people in the South of Scotland to vote yes in the referendum in September.
The spokesman was responding to the findings of an exclusive poll by ComRes for Representing Border, which said the majority of people in the South of Scotland would currently vote no.
"As we move closer to the referendum we will, of course, be stepping up our information campaign because we know from our own detailed research that the more people learn about independence the more likely they are to vote Yes.
"We will be campaigning hard in the South of Scotland as we will be in every other part of the country.
"We know we still have a lot of hard work to do to convince more people that taking our own future into our own hands makes sense for Scotland as well as the rest of the UK, but we are very much up for the challenge.
"Recent polls have shown that momentum is with us and we are confident that we can achieve a Yes vote on September 18."