This is the scene on the A66 at Threlkeld in the Lake District, where two vehicles collided.
Two adults and a boy aged 10 are seriously ill.
Two other children have also been taken to hospital.
More top news
The latest round of polls from Lord Ashcroft show the Scottish National Party has experienced a surge in 'no' as well as 'yes' voting areas.
The latest polling from Lord Ashcroft suggests the SNP is pushing the Unionist parties hard in our region.
A look ahead at the forecast for the Border region.