This is the scene on the A66 at Threlkeld in the Lake District, where two vehicles collided.
Two adults and a boy aged 10 are seriously ill.
Two other children have also been taken to hospital.
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Kerrie Gosney brings you Saturday night's forecast
Showers turning heavy with a risk of thunder. Dry and bright start on Sunday, cloudy and wet from the west later
Scotland's First Minister said her government will seek 'immediate discussions' with Brussels to "protect Scotland's place in the EU".