Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
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Peter Little was a passenger in a Landrover Discovery which collided with a Vauxhall Movano van near Newton Stewart, on 10 November 2017.
A woman has suffered serious head injuries after falling 20 meters down a rocky slope in the Lake District.
Susan Graham, aged 58, was last seen at Sainsbury's in Penrith on 20 November 2017.