Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
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Carlisle have secured their Football League status by beating Plymouth Argyle 2-0 at Brunton Park.
Kerrie brings you Saturday night's forecast
Carlisle are preparing for game that could see them safe from relegation. They welcome Plymouth Argyle to Brunton Park for a 3pm kick-off.