Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
More top news
Vigils have been held in the region to mark the 100th anniversary of the battle of the Somme.
Vigils will take place across the region tonight to remember those who fought in the Battle of the Somme 100 years ago.
In our Political Editor's latest blog; the Holyrood recess will be used to look at options for the future with the UK outside the EU.