Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
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Young's Seafood itself is now on the market. The potential sale is understood not to have an affect on the possible closure of Pinneys.
Scottish Secretary David Mundell is to meet with key figures as efforts to save the closure-threatened Pinneys seafood factory continue.
Scottish Parliament has been warned that the closure of Pinneys factory would be an 'economic tsunami' for Annan.