Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
More top news
Cumbria is launching its first full-time recruitment campaign in eight years and is keen to attract people from LGBT and ethnic backgrounds.
32-year-old Marie Staniforth has been found guilty of causing neglect and unnecessary suffering to her pet lurcher dog, Charlie.
New figures show that Copeland is the most miserable area in the ITV Border region, while Allerdale and Eden are the cheeriest.