Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
More top news
The second of our special reports looks at the history of the Borders Railway - starting with the closure of the Waverley Line in 1969.
Predominantly dry over the coming few days with variable cloud & some sunshine. Cool nights but daytime temperatures recovering a little
The two boys robbed a Carlisle store earlier this year, after threatening the lone female shop assistant with a knife.