Cumbria Police say the A66 will remain closed at Threlkeld "for the foreseeable future".
Diversions are in place.
People travelling from Keswick are asked to travel along St Johns in the Vale.
Those travelling from Penrith, will be turned round at Rheged and are advised to use the M6 routes.
More top news
A look at the forecast for the Tyne Tees region.
Cumbria County Council has got £2 million to spend on roads in the Lake District.
The Citizens Advice Service in Dumfries and Galloway is urging people to avoid debt this Christmas.