Edwina Sorkin and Kate Sleath are driving from Tebay to China, unaided and unsupported, to raise £150,000 for cancer charities.
The duo, who call themselves the Beijing biddies, aim to complete the challenge in thirty days.
Edwina and Kate say getting older should be no barrier to taking on big challenges.
They will travel through Holland, Germany, Poland, Lithuania and Latvia, right across Russia, and through Mongolia before reaching their destination.
A group of women, who call themselves the "Beijing Biddies and Babes" have set off on a 2,700-mile charity drive to the Arctic Circle.
Two pensioners from the Borders are preparing to tackle a 2,700 mile drive from Cumbria to the Arctic Circle.
Two grandmothers from Cumbria are beginning a challenge of a lifetime by driving themselves to China, to raise money for cancer charities.