Edwina Sorkin and Kate Sleath are driving from Tebay to China, unaided and unsupported, to raise £150,000 for cancer charities.
The duo, who call themselves the Beijing biddies, aim to complete the challenge in thirty days.
Edwina and Kate say getting older should be no barrier to taking on big challenges.
They will travel through Holland, Germany, Poland, Lithuania and Latvia, right across Russia, and through Mongolia before reaching their destination.
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Not a bad start to the week. A little chilly on Monday morning, any mist lifting quickly
Emma brings you ITV Border's Sunday Weather Forecast.
Clear start, patchy cloud at the east coast, some mist forming further west. Cool in the countryside