Edwina Sorkin and Kate Sleath are driving from Tebay to China, unaided and unsupported, to raise £150,000 for cancer charities.
The duo, who call themselves the Beijing biddies, aim to complete the challenge in thirty days.
Edwina and Kate say getting older should be no barrier to taking on big challenges.
They will travel through Holland, Germany, Poland, Lithuania and Latvia, right across Russia, and through Mongolia before reaching their destination.
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Carlisle have secured their Football League status by beating Plymouth Argyle 2-0 at Brunton Park.
Kerrie brings you Saturday night's forecast
Carlisle are preparing for game that could see them safe from relegation. They welcome Plymouth Argyle to Brunton Park for a 3pm kick-off.