No one is thought to be injured at the fire at the Cumbria Waste Management Centre, Kingmoor Road, in Carlisle.
Emergency services are still dealing with the fire and the road has been closed from the bypass, down to the junction at Hartley Avenue.
At this time no one is believed to have been injured.
Emergency services are urging people in the area to stay indoors and close their windows and doors to protect themselves from the smoke.
Motorists are advised to avoid the area and seek alternative routes.
More top news
A look ahead at the Bank Holiday forecast for the Border region.
Cumbria County Council will start work on a £320,000 resurfacing scheme on 6 June, between 6.00pm and 12.30am.
ITV Border's favourite Tapir has left the Lake District Wildlife Park near Keswick, to travel to his new home in the United Arab Emirates.