No one is thought to be injured at the fire at the Cumbria Waste Management Centre, Kingmoor Road, in Carlisle.
Emergency services are still dealing with the fire and the road has been closed from the bypass, down to the junction at Hartley Avenue.
At this time no one is believed to have been injured.
Emergency services are urging people in the area to stay indoors and close their windows and doors to protect themselves from the smoke.
Motorists are advised to avoid the area and seek alternative routes.
More top news
Windy and colder. Rain or showers - some of which will be wintry on hills with some snow settling over highest ground. Some sunshine around
The Carlisle United Trust has voted overwhelmingly in favour of proposals to bring a £1.26 million investment to the club.
Cumbria Police has defended its decision to spend one £1.8 million on replacing traditional notebooks with new electronic devices.