No one is thought to be injured at the fire at the Cumbria Waste Management Centre, Kingmoor Road, in Carlisle.
Emergency services are still dealing with the fire and the road has been closed from the bypass, down to the junction at Hartley Avenue.
At this time no one is believed to have been injured.
Emergency services are urging people in the area to stay indoors and close their windows and doors to protect themselves from the smoke.
Motorists are advised to avoid the area and seek alternative routes.
More top news
Outbreaks of sleet or snow, breezy and turning very cold, the wind chill making temperatures feel like sub-zero. Warnings for snow and ice
Cumbria Police are looking to recruit more than 100 new police constables, just months after the force had been threatened by budget cuts.
The River Kent is being dredged again after more storms at the end of January washed up to 100 tonnes of gravel back downstream