The A701 has reopened at Beattock following a late night incident involving an overturned tanker.
Emergency services were called to the crash at the junction with the B7076 to Johnstonebridge and Lockerbie.
The articulated tanker overturned and landed on its side but the driver is thought to have suffered only shock and bruising.
Scottish Fire and Rescue Service personnel, ambulance staff and police were called to the scene but there was no leakage from the tanker which is believed to be loaded with a powder.
Diversions were set up on both sides of the crash scene and the road was closed for much of the night.