A 22-year-old woman and a 2-year-old boy are in a 'serious condition' in hospital after a one-car crash near Airyhassen.
It happened yesterday morning on the B7085 between Whaphill and Port William.
The woman and child were airlifted to Queen Elizabeth Hospital in Glasgow where they remain receiving treatment.
The road was closed for seven hours but has since reopened.
Anyone with information is asked to call 101.