The tour will begin at Leeds Arena, where the Queen will unveil a plaque at the £60m venue, which is currently under construction.
Her Majesty, along with the Duke of Edinburgh, will also go to the recently renovated City Varieties and take part in a walkabout on Briggate.
Leeds Council have said space will be limited on Briggate and people should arrive no later than 11am.
During the walkabout, singers from different choirs across Leeds will give a performance.
At the City Varieties, the Queen and Duke of Edinburgh will hear about Leeds' plans to be a Child Friendly City and watch a performance by the theatre's youth company.