North Lincolnshire Council are assembling a "task force" to help workers facing job losses at Kimberley Clark in Barton.
378 workers were given the news yesterday the American hygiene giant would almost stop its manufacturing of nappies in Europe.
The firm has been criticised for axing the jobs despite receiving a multi-million pound Government grant to open its factory on the Humber.
The factory was set up 20 years ago with a public subsidy of £12m – a grant that would be worth £20m in today's prices.
It's the third major blow to East Yorkshire in days. Seven Seas has announced plans to close its Hull site, and almost half of the workforce based at McCain are in danger of losing their jobs.
Hull East MP Karl Turner said: "Companies are too quick to take local government money and then desert us when times get tough.
"This is more money out of the local economy and more pain for families."
Kimberly-Clark's announcement brings the total number of potential job losses across the region to almost 800 in less than two weeks.
Cleethorpes MP told Calendar: "The area does show signs of picking up but of course there are no immediate job prospects. There are a lot in the pipeline we know with the various developments, to do with the renewables sector, but that's a long way away and what we've got to do is make sure every possible help is given to the employees affected.
"I shall be visiting the factory on Friday to satisfy myself the company are doing all they can and I'm contacting all the various Government agencies to make sure they're doing their bit."
"It looks like, if we are absolutely honest, it would appear the company has taken this decision at an international board level to more or less pull out of Europe completely, so I doubt whether they would be persuaded otherwise. But I will obviously be raising that possibility with them and with the appropriate Government departments."