"We're worried that this is the first bank holiday following the launch of 111. At a time where 111 in parts of the country is fragile, we need to plan as well as we can".
The college said it has noted the "very serious concerns" being expressed about the efficiency and effectiveness of NHS 111 around the country.
"We have strong reservations and concerns about the amount of investment that has gone into providing clinical support to the computerised decision algorithms being used to help the public seek the service that is most appropriate to them, " a spokesman said.
The warning comes as at least 22 "potentially serious" incidents - three involving deaths - have been recorded in connection with the service, according to health magazine Pulse.
A spokesman from Derbyshire Health United - which covers NHS 111 in Derbyshire, Nottinghamshire and Northamptonshire - said it was investigating the two deaths but so far it believes the system and processes that were followed would have been "exactly as expected".
NHS Direct - which covers eight NHS 111 areas - said it is investigating the unexpected death of a patient who was referred to a GP out-of-hours service in the West Midlands, Pulse reported
NHS England's board members have voted to set up a review into the service