North Yorkshire Police is asking motorists to avoid the A64 between Highwayman Cafe and Hopgrove roundabout due to a serious crash.
A woman suffered serious injuries after her car hit a bus and then a shop on the A64 near Leeds.
A spokesman for West Yorkshire Police said: "At around 1.50 today we were called to a crash on the A64.
"A woman's car had come off the road after hitting a bus, then a shop window.
"She was taken to hospital with serious injuries, but they are not thought to be life-threatening.
"Nobody else was injured."
Police are appealing for witnesses after a woman was seriously injured in a crash on the A64 near York. It happened around 7am, after a black car left the westbound carriageway at Bilborough and landed in a ditch. It is believed the woman driving the car had been seriously injured in the accident.
Both lanes of the westbound carriageway are currently closed while police investigate the circumstances of the collision. The A1237 is also closed to stop vehicles trying to access the carriageway.
A man who drove the wrong way along a dual carriageway in York while drunk has been handed a suspended prison sentence.
27-year-old Sandeep Singh Cheema from Leeds caused a serious crash when he was driving eastbound on the westbound carriageway of the A64 in June this year.
As a result a car that was going in the correct direction had to swerve, causing it to leave the road, where it then rolled down and embankment and flipped onto its roof. One of the people inside was taken to hospital with a broken elbow and shoulder.
Cheema eventually stopped and arrested by police. When he was breathalysed he was more than twice the legal drink driving limit.
He was sentenced to eight months’ in prison suspended for two years. He was also ordered to undertake 240 hours of unpaid work and banned from driving for 18 months.
Work will take place on the A64 near Bramham, to resurface sections of the carriageway and improve the existing road markings. The work will take place at Bramham Roundabout (A1(M) Junction 44) and on the east and westbound carriageway from Bramham to Headley Bar.
Work will begin this morning and is due to be completed on Friday 17 August. The work will take place overnight on Monday to Thursday nights only, from at 8pm until 6am. If works are cancelled due to weather, they will take place on subsequent nights.
For safety reasons a 50mph speed limit will be in place. There will be lengths of convoy working and traffic signals in use on 13 and 14 August on the A64 eastbound carriageway and on 15 and 16 August on the A64 westbound carriageway. During this time, there will be a 10mph speed limit in place.
A man has died after he was knocked down in Leeds.
It happened at 10.45 on Saturday at the Red Bus Cafe layby on the A64 when a 20-year-old man was in collision with a car. The driver of the car stopped at the scene. Anyone who witnessed the accident is urged to come forward.**