The new aircraft, known as 13 Squadron, which were officially "stood up" in October, started flying missions over Afghanistan this week from their base in Lincolnshire.
The hi-tech Reaper drones are primarily used to gather intelligence on enemy activity on the ground, but they also carry 500lb bombs and Hellfire missiles for precision strikes on insurgents.
An MoD spokesman said they had been carrying out missions including intelligence, surveillance and reconnaissance, but would not comment on exactly what individual missions had been flown in the past week by drones piloted from the UK.
A Ministry of Defence decision to base drones in the UK for the first time has been met with hostility by protesters. The spy planes are now based at RAF Waddington in Lincolnshire.
Several protest groups will be marching against the decision by walking from Lincoln station to the main gate at RAF Waddington today.
Ahead of a planned protest outside an RAF base today against the UK's use of armed drones in Afghanistan, War on Want senior campaigns officer Rafeef Ziadah said:
Drones, controlled far away from conflict zones, ease politicians' decisions to launch military strikes and order extrajudicial assassinations, without democratic oversight or accountability to the public.
"Now is the time to ban killer drones - before it is too late.
Drone missions over Afghanistan have been flown by RAF pilots operating on British soil for the first time.
Until this week, RAF crews who control armed drones in Afghanistan have been operating from the USA Creech Air Force Base in Nevada.
Last year the Ministry of Defence (MoD) announced that the UK was doubling the number of armed RAF drones in Afghanistan to 10 with the five new aircraft to be operated remotely from RAF Waddington in Lincolnshire.
Anti-war protesters are set to gather outside an RAF base today to voice their opposition to the UK's use of armed drones in Afghanistan.
Members of the Stop The War Coalition, CND, The Drone Campaign Network and War on Want will march from Lincoln to nearby RAF Waddington.
The RAF began remotely operating its Reaper unmanned aerial vehicles deployed to Afghanistan from the Lincolnshire airbase earlier this week.
In a statement, the RAF said it had started supporting the International Security Assistance Force and Afghan ground troops with "armed intelligence and surveillance missions" remotely piloted from RAF Waddington.
The aircraft were previously operated from a United States Air Force base in Nevada.
More than 100 soldiers have returned safely to their base in North Yorkshire following a tour of duty in Afghanistan.
The soldiers from 4th Regiment Royal Artillery were met by their families at Alanbrooke Barracks, near Thirsk, last night.
The 'North East Gunners' had been helping to train Afghan special forces as the withdrawal of British troops continues.
You can watch the full report from Jonny Blair below.
Troops from 4th Regiment Royal Artillery have returned to Alanbrooke Barracks after a six month tour of Afghanistan.
Troops returning to North Yorkshire have received a warm welcome from loved ones after a six month tour of duty in Afghanistan.
Soldiers from 4th Regiment Royal Artillery have been enjoying time with friends and family following a six month tour of Afghanistan. They arrived back at Alanbrooke Baracks in North Yorkshire.
More than one hundred soldiers have safely returned to their base in North Yorkshire following a six month tour of Afghanistan.
Troops from the 4th Regiment Royal Artillery arrived at Alanbrooke Barracks where they were greeted by loved ones.