14-year-old Jessica Magee was last seen on Tuesday evening in Balby. She told her mother that she was leaving and had packed some make up and clothes, including her Balby Carr school uniform, and that she would attend school the following day.
Jessica did not attend school the next day and has not been seen or heard from since.
She is described as white, approximately 5ft 4ins tall with long, dark hair.
Police are appealing for anyone with information about where she might be to get in touch.
A fourth person has been arrested after a man's body was found at house in Balby Doncaster.
Officers were called to a house on Burton Avenue in Balby on Wednesday 3 October where the deceased, Mark Stannard, lived with two other men.
A 33-year-old woman from Doncaster has been arrested on suspicion of murder and is being questioned by police.
The three other people that were previously arrested on suspicion of murder, two men aged 51 and 34-years-old and a woman, all from Doncaster have been released on bail until December 2012, pending further enquires.