Barnsley will be without Jim O'Brien at Watford after the midfielder suffered a season-ending knee injury at home to Leicester in midweek.
Central defenders Peter Ramage and Martin Cranie were both forced out of Tuesday night's match with hamstring injuries and are set to miss out again.
Long-term absentee Bobby Hassell (calf) is still struggling and Ryan McLaughlin, (hamstring) is not ready to return following a hamstring problem.
Barnsley midfielder Jim O'Brien is expected to return for Barnsley against Nottingham Forrest after missing last week's 5-0 defeat at Huddersfield through illness.
Norwegian striker Marcus Pedersen misses out after sustaining a knock on international duty, while Paddy McCourt (Northern Ireland) and Brek Shea (United States) are expected to return unscathed.
Tomasz Cywka hopes to return to the squad after missing out last week, while fellow midfielder Martin Woods and defender Jean-Yves Mvoto are pushing for recalls.
Barnsley football club have issued an apology after heated exchanges between their players and fans following their 5-0 defeat against Huddersfield at the weekend.
An investigation was launched after midfielder Stephen Dawson and winger Brek Shea responded to a section of angry fans at the John Smith's Stadium on Saturday.
Barnsley fell to the bottom of the Sky Bet Championship table after suffering their biggest defeat of the season and Dawson became embroiled in a row with a fan while Shea is alleged to have made an offensive hand gesture.
A statement by the club said: " As a club, we do not condone any provocative actions from any of its employees and would like to further apologise for any offence caused.
Stephen Dawson has apologised unreservedly for his actions and will be making a substantial donation to Barnsley Hospice by way of an apology.
In relation to an alleged incident concerning Brek Shea the matter is currently under investigation and a further statement will be made upon Brek's return from international duty.
Barnsley Football Club would like to apologise unreservedly for any offence caused and assure supporters such actions will not be repeated."
Sheffield Wednesday will be looking to maintain their recent improvement under Stuart Gray against Barnsley, who desperately need points to follow the Owls out of the Championship relegation zone, as the sides meet in the South Yorkshire derby.
John Shires looks ahead to the game at Hillsborough:
Barnsley have moved to quash speculation about a rumoured takeover at the club.
In a statement on their website, the club say "unsolicited approaches" to owner, Patrick Clyne, causing the speculation.
The club say no offers are being considered at the moment.
Barnsley's new signings Liam Lawrence and Ryan McLaughlin could make their first appearances for the club while Brek Shea is poised for his home debut.
Boss Danny Wilson will be without defender Bobby Hassell (calf), midfielder Kelvin Etuhu (hamstring) and striker Marcus Pedersen (thigh). Winger Jim O'Brien has a groin problem, but is expecting to be included in the squad.
Wilson is still chasing his first win since returning to the club last month, with the Tykes without a win in their last six league games.
Barnsley have announced the signing of promising Liverpool Academy full back Ryan McLaughlin on a one month loan.
Danny Wilson's side are bottom of the Championship, five points adrift of safety.
McLaughlin has been with the Reds since 2011, featuring on their 2013 pre-season US tour and has represented Northern Ireland at youth level.
Danny Wilson is back as manager of Barnsley - 15 years after leaving the club.
Wilson was the man who led the Tykes to the Premier League back in 1997 but returns with the club fighting for their Championship lives.
Barnsley are still yet to appoint a permanent successor to David Flitcroft, who was sacked last weekend.
Flitcroft's assistant Mickey Mellon was in charge for the Tykes midweek win at Brighton and another positive result at Burnley tomorrow will do his chances of being handed the reins on a permanent basis no harm.