More than 100 journalists and engineers at the BBC's studios in Leeds, Hull and Sheffield are due to walk out en masse at mid-day.
Members of the National Union of Journalists (NUJ) and technical union Bectu voted in favour of the walkouts.
The latest industrial action follows a one-day strike by NUJ members on February 18 which affected programmes.
Another strike by union members in Scotland that had been due to take place on Friday and Monday has now been called off.
The BBC is cutting about 2,000 jobs over five years as part of its Delivering Quality First programme.