Inactive lifestyles cause 37 000 premature deaths a year, and costs society more than 8 billion pounds, according to a new report.
The figures published by UK Active showed 30% of people in Yorkshire and Northern Lincolnshire don't do enough physical activity - that's 1% more than the national average.
Hull was named the fifth most inactive place in the country.
The Chief Medical Officer defines physical inactivity as participation in less than 30 minutes of moderate intensity physical activity per week.
The report found "Incontrovertible evidence that inactivity significantly heightens the risk of developing chronic illnesses."
It also found there is a disproportionately low spend on programmes to tackle physical inactivity by local authorities, but that Yorkshire and the Humber spends much more on this than the national average.
But the East Midlands has one of the lowest proportional public health spends on physical inactivity (1.8 per cent) compared to the national average (2.4 per cent). The region is just below average in terms of inactivity.