Hull midfielder David Meyler could miss up to two months after sustaining a knee injury while on international duty with the Republic of Ireland.
The 26-year-old has suffered a tear to his medial ligament after colliding with Stoke defender Marc Wilson during a training session ahead of Ireland's Euro 2016 play-off.
The club posted the injury update on their official website, with their doctors predicting Meyler will be out for up to eight weeks.
Meyler has scored three goals for the table-topping Tigers this season as Steve Bruce's side look to gain promotion back to the top-flight at the first time of asking.
The draw for the quarter finals of the Capital One Cup hasn't been kind to either Sheffield Wednesday or Hull City - with both clubs facing difficult away ties against Premier League opposition.
The Owls travel to Stoke, while Hull have a daunting trip to Manchester City.
The ties will be played on the week commencing 30th November.
Hull City have booked their place in the quarter-finals of the Capital One Cup after a 5-4 win on penalties over Leicester City at the KC Stadium.
After a goalless 90 minutes, Riyad Mahrez gave Leicester the lead - only for that to be wiped out by Abel Hernandez soon after.
Mahrez missed the only spot-kick of the shootout and it proved costly as David Meyler stepped up to net the winner and send the home crowd into raptures.
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Hull City captain, Curtis Davis has shown that there's more than one physical striker currently plying their trade in the Premier League.
The defender tweeted marks on his face from one of Swansea City's strikers, either Bafetimbi Gomis or Eder, who played in the Tigers 1-0 Capital One Cup win over the South Wales club:
Hull City midfielder, Jake Livermore, has tweeted thanks for the support he received from his tea mates and fans while the FA decided on his punishment for failing a doping test.
Livermore had been suspended since April, and made his comeback in last night's 1-0 victory over Swansea in the Capital One Cup:
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