Amanda Knox's legal team says it fully expects her to be proved innocent at retrial.
Speaking to NBC's Today show, Theodore Simon says nothing has changed and insisted "there was no evidence before, and there is no evidence now".
Watch the interview in full from NBC News.
Speaking to American breakfast show, Good Morning America, Amanda Knox's lawyer said:
There's simply no evidence, there never was, there never will be.
Raffaele Sollecito says he is "disappointed" that his acquittal has been overturned in Italy.
Speaking to the Italian news agency, ANSA, Lawyer, Luca Mauri said: "Today is his birthday, he's 29. He shouldn't be disappointed because he's innocent. He thought the end could be coming to this affair".
Amanda Knox and Raffaele Sollecito have been ordered to face retrial for the murder of British exchange student Meredith Kercher.
Meredith's body was found in her apartment in Perugia on November 2, 2007. Here are the key events in the six year saga:
Speaking to ITV News from the family home in Coulsdon in south London, Meredith Kercher's sister Stephanie said:
We welcome the news in the sense that we hope to find the answers. We are never going to be happy about any outcome because we have still lost Meredith but we obviously support the decision and hope to get answers from it.
There are still so many unanswered questions, all we have ever wanted to do is do what we can for Meredith and to find out the truth of what happened that night.
Rudy Guede's conviction was on the basis that there was more than one person there so that is something that needs to be looked into.
– Luciano Ghirga, Defence lawyer for Amanda KnoxWhat do we expect? A decision based on justice, so we expect a good outcome.
It was painful to receive the news that the Italian Supreme Court decided to send my case back for revision when the prosecution's theory of my involvement in Meredith's murder has been repeatedly revealed to be completely unfounded and unfair.
I believe that any questions as to my innocence must be examined by an objective investigation and a capable prosecution.
– Amanda KnoxThe prosecution responsible for the many discrepancies in their work must be made to answer for them, for Raffaele's sake, my sake, and most especially for the sake of Meredith's family.
Our hearts go out to them. No matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity.
In a statement, Amanda Knox added that the prosecutors' theory of her involvement in the murder is "completely unfounded and unfair".
– Amanda KnoxNo matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity.
– Amanda Knox's lawyer, Carlo Dalla VedovaIf she is convicted at that trial and if the conviction is upheld by the highest court, then Italy could seek her extradition.
