The family of a teenager who was beheaded by her boyfriend have spoken of their pain after her killer was jailed for life for murder.
Medical researchers in Sheffield have discovered that diabetic nerve damage causes more harm in the brain than previously thought.
A look into the technology which enabled a profoundly deaf woman to hear for the first time after 40 years.
A breast cancer drug that can extend life by almost six months has been turned down for use on the NHS because it is too expensive.
NICE - the National Institute for Health and Care Excellence says at £90,000 per patient the drug Kadcyla - which was trialled in Sheffield - is too expensive and the cost can't be justified.
But the decision has come under fire from doctors, people with cancer and also those who've lost loved ones to the disease.
David Hirst reports:
A new drug for breast cancer which was trialled at a Sheffield hospital will not be routinely available on the NHS.
Health chiefs say Kadcyla, which can extend patient's lives by six months and underwent trials at Weston Park Hospital, is too expensive to roll out across the country.
It can cost more than £90,000 per patient.
The decision by NICE, the National Institute for Health and Care Excellence has been criticised by patient support groups.
Debra Horsman works for Haven which is a Leeds based charity:
Sheffield Council is to give £500,000 towards a multi-million pounds revamp of the city's Lyceum Theatre.
The council has given formal approval for the grant to Sheffield Theatres, which wants to install new equipment and seating to help boost audience numbers.
Earlier this year the Arts Council agreed to give £1 million towards the work which is due to start this summer.
A new drug for breast cancer which extends women's lives by almost six months is to be blocked from routine NHS access under draft guidance issued by a health watchdog.
Trialled at Sheffield's Weston Park Hospital, Kadcyla, manufactured by Roche, can cost more than £90,000 per patient and is not effective enough to justify the price the NHS is being asked to pay, the National Institute for Health and Care Excellence (Nice) said.
A controversial poster campaign by UKIP leader Nigel Farage has been bankrolled by a Yorkshire multi millionaire businessman.
The anti-immigration campaign which claims "British workers are hit hard by unlimited foreign labour" has been attacked as 'racist' by their political opponents.
The man who has financed the advertising campaign ahead of the European parliamentary elections next month is Paul Sykes, who built Sheffield's Meadowhall shopping complex.
The search has started for a man after a 12-year-old girl was attacked on waste ground in Sheffield.
It happened on 15 April in the Grimesthorpe area of the city, when she was walking along Barnsley Road towards Earl Marshal Road.
The man grabbed her and pinned her to the floor. He allegedly sexually assaulted her before running off towards Barnsley Road.
The man is described as Asian, in his 20s, with side burns and a little fringe. He was reportedly wearing a grey and yellow hooded top with blue writing on the front, black trousers and black trainers.
Anyone with information is asked to contact South Yorkshire Police.
A school principal from Derbyshire has managed to fulfil a lifelong dream to meet Gary Barlow.
Angela O'Brien who is principal at Wyndham Primary Academy in Alvaston masterminded a plan to appear on stage with Gary Barlow at his show is Sheffield.
She made a banner, booked two front row seats and even tweeted Gary Barlow in advance with #anythingispossible.
The idea was to show her pupils that you can achieve your dreams.
The campaign to find Ben Needham has taken to Twitter for a special "Tweet for Ben" day.
The Sheffield toddler went missing on the island of Kos in 1991.
The account @FindBenNeedham is tweeting high-profile celebrities to raise awareness of their search.
A thousand bikers have taken part in the annual Easter Egg Run, delivering eggs to patients at Sheffield Children's Hospital.
Among them was World Superbike Champion and Children's Hospital Charity patron James Toseland.
He led the convoy through the city before arriving at the hospital this morning.