Jeremy Hunt called on NHS bosses to end the use of legal gags on whistleblowers.
In a letter to the chairmen of every Trust, the Health Secretary warned against a culture in some quarters of "institutional self defence that prevents honest acknowledgement of failure".
He said that in order to avoid a repeat of the Mid-Staffordshire scandal it was vital to "recognise and celebrate staff" who had the "courage and professional integrity" to speak out over safety concerns.
It comes after a former NHS employee, who previously worked for United Lincolnshire Hospitals Trust, told Calendar News she was subjected to unrealistic targets and at times felt bullied by the pressures placed upon her whilst working there.
More top news
Emma Jesson has the latest.
The Tigers midfielder Ryan Mason has undergone surgery after fracturing his skull after a clash of heads during Sunday's game at Chelsea.
It is thought Gerry Newman and her children were killed by her estranged husband who then took his own life last year.