The 44-tonne lorry was carrying a load of around 10 tonnes of frozen fish, much of which spilled onto the road.
The lorry itself is blocking the whole road and some of the frozen salmon has also spread over onto the opposite carriageway.
A full closure is currently in place at junction 34 eastbound of the M62 with diversions via the A19 and A645 or the A19, A63 and A1041 for high vehicles.
The closure is expected to remain in place for some time.
More top news
It is now 12 months since a jury ruled that 96 football fans who lost their lives in the Hillsborough tragedy were unlawfully killed
Jon Mitchell has the early morning forecast for Wednesday
The actress plays Rhona Goskirk, who was raped by her new husband on their wedding day in the ITV soap.