Karl Milner, the executive director of Leeds Teaching Hospitals NHS Trust, tweeted: "[Leeds General Infirmary] major trauma centre put on alert following pile up on M62 near Castleford".
Motorists have been advised to use the M18 or M1 instead. The carriageway is not expected to reopen until 6pm tonight.
The brother of M62 crash victim Bethany Jones has paid a touching tribute to the 18-year-old.
A vigil has been held for the victims of the M62 crash in West Yorkshire, including 18-year-old Bethany Jones, who died at the scene.
A lorry driver has been arrested after 19 people were injured, six of them seriously, in a crash with a minibus in West Yorkshire.