Over 2,000 local people have signed a petition calling on the Government to keep essential funding for GP practices who serve patients with higher and more complex health needs.
It calls for a halt to cuts which threaten 100 GPs practices with closure across the country - including two in central Sheffield.
The petition was started in January by staff and patients at the Devonshire Green and Hanover Medical Centres who are one of the 100 affected.
Today a group of doctors, staff and patients will join Sheffield Central MP Paul Blomfield to hand in the petition at No.10 Downing Street.
Mr Blomfield helped launch the petition and has challenged Ministers on the issue in Parliament on several occasions. Whilst in Westminster the group will also meet with a Government Health Minister and Labour's Shadow Secretary of State for Health Andy Burnham.
The petition was launched to challenge the Government's decision to axe a special funding stream called the Minimum Practice Income Guarantee (MPIG).
MPIG funding supports GP surgeries, such as Devonshire Green and Hanover Medical Centres and also Sharrow Lane Medical Centre, which serve areas with above-average health needs.
Cutting this funding will mean some GP practices lose as much as £140,000 income. It is estimated that this loss of funding means four or five practices in Sheffield- all in areas of high need - may be forced to close.