Charlotte Avenall from Mansfield, an eight-year-old with learning disabilities, was found hanged by a window cord in her squalid bedroom.
Police said the room was the most shocking they had seen.
Keanu Williams was just two years old from Birmingham.
He died from a fractured skull and a torn abdomen, his mother manipulated social workers into believing she was a competent mother.
And now Daniel Pelka, the four-year-old was starved, beaten and tortured for months before suffering a fatal head injury at his home in Coventry.
So how can we begin to understand what makes a parent, or carer of a child behave in this way?
Daniel Pelka’s death is all the more shocking because it was caused by the very people who were supposed to love, and nurture him.
And his is not an isolated case.
There have been a number of high profile child deaths at the hands of parents and carers in the Midlands, in recent years.
Jade Sinclair from Lincoln was three-years-old when she died.
There were a hundred injuries on her body when she died, a pathologist said it was the worst case of child abuse he had seen in 30 years.
Seven-year-old Khyra Ishaq from Birmingham.
She was beaten and starved to death by her mother and stepfather, police officers were moved to tears at the sight of her body.
Ryan Lovell-Hancox from Wolverhampton, three-years-old and was thrown across a room, locked in a cupboard and punched by babysitters.
The judge said they showed more concern for their dogs than Ryan.
For every one child on the child protection register, another eight are being mistreated behind closed doors.
Often the signs are there but they are just not acted upon, either because people fear getting involved, or because the abuser is so convincing.
There is no typical abusive parent, but there are a number of triggers.
When a young child is severely neglected their behaviour alters dramatically.
A common theme in cases of child cruelty is starvation.
Parents using food as a means of control.
But despite the obvious signs that Daniel was getting thinner, and scavenging for food, he slipped through the safety net.
Child cruelty often starts as emotional abuse - the child is told they are not wanted, they are rejected by their family.
Child safety campaigners want emotional abuse treated as a crime in the same way as physical or sexual abuse.
No one likes to think of a parent or carer deliberately harming a child, which is why those responsible for the deaths of these children were not brought to task until it was too late.
But the message from Child Protection Agencies is clear.
It is our collective responsibility to report suspicions, and to protect the vulnerable.