Liverpool v Notts County (KO 19.45)
The pick of tonight's action will be at Anfield where League Two side, Notts County, play Liverpool.
The Magpies have started the season poorly, losing three out of four games. Their only win came in the first round of the Capital One Cup against League Two side Fleetwood Town.
Notts County boss, Chris Kiwomya, may have to cope without captain Dean Leacock (leg), Alan Sheehan (hamstring), Danny Haynes (knock) and Enoch Showunmi (back) who all missed Saturday's 1-0 loss to Stevenage.
Liverpool have made a strong start to the season, beating Stoke City and Aston Villa. With a game against Manchester United this Sunday Reds manager, Brendan Rodgers, might use tonight's game to field youngsters, including Raheem Sterling and new signing Luis Alberto.
West Brom v Newport (KO 20.00)
West Brom must make do without Nicolas Anelka, who is on compassionate leave and goalkeeper, Ben Foster, is also missing after injuring his ankle in Saturday's draw with Everton.
The Baggies have never previously faced the Welsh team.
Burton Albion v Fulham (KO 19.45)
League Two side, Burton Albion, host Premier League Fulham at the Pirelli Stadium tonight. Full-back, Chris Hussey, is likely to play after scoring twice against Sheffield United in the last round.
Burton have never faced Premier League opponents in the League Cup before and are looking to continue an impressive unbeaten start to the season.
Fulham have a poor record in the Capital One Cup and visit a team tonight which had the best home record in the country last season.
Carlisle v Leicester (KO 19.45)
Leicester will look to continue their strong Capital One Cup away form, but must do so without the injured Sean St Ledger.
The Foxes play a side which has failed to beat them since 1969.
Derby v Brentford (KO 19.45)
Jeff Hendrick is likely to miss tonight's game. Derby's 21-year-old central midfielder hurt his ankle in Saturday’s 3-0 win at Yeovil Town and had to be substituted.
Rams boss Nigel Clough expects Hendrick to miss the match against Uwe Rosler’s Brentford side.
The last time the teams met was in the FA Cup in 2003, where Brentford won 1-0.
Peterborough v Reading (KO 19.45)
Darren Ferguson has said he will definitely make changes for tonight's game. The Posh manager said Jack Payne will be involved and Grant McCann may be rested.
Peterborough have won every game this season, including a 5-1 victory over Colchester United in the last round of the cup.
The teams played each other in the same round last season, with the Royals beating their then Championship opponents 3-2.
West Ham v Cheltenham (KO 19.45)
Cheltenham manager, Mark Yates, has described the visit to Upton Park as a great experience.
But the Robins must play without veteran striker, Jamie Cureton, who dislocated his shoulder on the first day of the season.
West Ham are likely to give youngsters including former Birmingham City player, Ravel Morrison, a run-out.
This is the first time West Ham and Cheltenham have ever played each other in any competition.
Yeovil v Birmingham (KO 19.45)
Birmingham visit their Championship rivals with a number of injuries in the squad. Shane Ferguson was forced off in Saturday's 3-2 loss to Leicester with a groin problem. Mitch Hancox and young Dutchman Akwasi Asante are also out.
Yeovil will be without recent loan signing, Andy Williams, who is cup-tied.
Birmingham have won the competition twice, most recently in 2011 when they famously beat Arsenal.
The sides met earlier this month for the first time ever, with Birmingham winning the Championship fixture 1-0.