1,300 puppies are born at the centre every year.
They currently have 272 breeders.
There are only eight breeders left on the waiting list.
On average six to eight breeding bitches are placed every month, but for the last three months of 2012 homes had to be found for around 15 dogs.
The Guide Dogs National Breeding Centre in Warwickshire is warning that they are running seriously low of people to look after their breeding bitches and puppies.
They say that if no-one new comes forward, they will run out of placements for the dogs within two to three months.