At least 22 "potentially serious" incidents - three involving deaths - have been recorded in relation to the new NHS 111 advice line, a health magazine reports. The deaths are being investigated. NHS England is keeping a 'careful eye' on the service.
"We're worried that this is the first bank holiday following the launch of 111. At a time where 111 in parts of the country is fragile, we need to plan as well as we can".
The college said it has noted the "very serious concerns" being expressed about the efficiency and effectiveness of NHS 111 around the country.
"We have strong reservations and concerns about the amount of investment that has gone into providing clinical support to the computerised decision algorithms being used to help the public seek the service that is most appropriate to them, " a spokesman said.
The warning comes as at least 22 "potentially serious" incidents - three involving deaths - have been recorded in connection with the service, according to health magazine Pulse.
A spokesman from Derbyshire Health United - which covers NHS 111 in Derbyshire, Nottinghamshire and Northamptonshire - said it was investigating the two deaths but so far it believes the system and processes that were followed would have been "exactly as expected".
NHS Direct - which covers eight NHS 111 areas - said it is investigating the unexpected death of a patient who was referred to a GP out-of-hours service in the West Midlands, Pulse reported
NHS England's board members have voted to set up a review into the service
Most NHS 111 providers have provided a good service but a small number have not.
There has been a vastly improved picture of NHS 111 compared with late March and the Easter Bank Holiday periods where problems were widely reported. Since that time, NHS England have put in place tighter controls.
We recognise the service may continue to have problems in some areas and therefore the 0845 46 47 number remains in place along with other out of hours services to ensure resilience in those places.
NHS England is to commission a review to learn vital lessons from how the NHS 111 service has been prepared and launched to date. The review will seek to identify the reasons for any deficiencies in the service to avoid similar problems when implementing the rest of the service and other future programmes.
NHS 111 has been running successfully in many areas of the country for a considerable time and public satisfaction with the service in these areas is high - 93% of those using the service were either satisfied or very satisfied with the service in the February 2013 figures.
The safety of patients must be our paramount concern and NHS England will keep a careful eye on the situation to ensure NHS 111 provides not only a good service for the public but one which is also safe.