The Derbyshire house formerly owned by Mick Philpott has been razed to the ground.
The fire-ravaged home was pulled down after the blaze which killed all six of the man's children.
Parents Mick and Mairead Philpott were jailed in April, with friend Paul Mosley, after being found to have started the petrol-fuelled fire.
The three were convicted of killing the couple's six children.
More housing will be built on the site following the work.
The house in Derby where six children died in a house fire is being demolished. The demolition has been underway for nearly three hours this morning, after workmen spent the last week preparing the house for its destruction.
Parents Mick and Mairead Philpott have been jailed for their childrens' murders.
The demolition of the Philpott house in Derby has begun.
Last week, workmen began preparations for its destruction, and earlier this morning, the neighbouring property was taken down.
Six children were killed in a house fire at the home in Victory Road, Allenton, in May 2012. Mick and Mairead Philpott, and their friend, Paul Mosley, have been jailed for their murders.
Demolition work is underway on the neighbouring property to the Philpott house in Derby.
Preparation work to take down both semi-detached houses in Victory Road, Allenton, began last week, but the demolition has begun in earnest this morning.
Work to demolish the major part of a house where six children died in a fire will get underway this morning.
Contractors prepared the former home of Mick and Mairead Philpott for demolition last week in Derby.
Bulldozers will start to take down the walls today.
Demolition work begins today at the house where the six children of Mick and Mairead Philpott died in a house fire.
Councillor Baggy Shanker from Derby City Council said local residents will always remember the children, but it is time to remove any physical reminder of the property where the children died.
The grandmother of six children who died in a house fire said they will be able to rest in peace now their former home is being demolished.
Vera Duffy, Mairead Philpott's mother, said she had wanted to see the start of the demolition process to end the tragic chapter in the family's history.
Derby City Council said the process of demolition is likely to take up to three weeks; one week to prepare the site and a further two weeks to take down both properties, beginning with the outbuildings and roofing structures.
New social housing is expected to be built on the site.
Demolition work has started at 18 Victory Road in Derby, where the six children of Mick and Mairead Philpott died in a fire.
The house and a neighbouring property are due to be demolished over the next three weeks.
Demolition of the house in Derby where six children were killed in a house fire starts today.
The fire which killed the six children took place on 11th May 2012.
In April this year Mick Philpott, his wife Mairead, and their friend, Paul Mosley, were all found guilty of manslaughter following a seven week trial at Nottingham Crown Court.
Mick Philpott was jailed for life. Mairead Philpott and Paul Mosley were both jailed for 17 years. Both Mairead and Mosley are appealing against their sentences.
The site will be developed into new housing.