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Scotland Yard, who have taken over the investigation into the disappearance of Madeleine McCann, say the version of what happened the night she went missing has changed significantly.
A reconstruction of the events in Portugal leading up to Madeleine's disappearance will be broadcast tomorrow, on BBCs Crimewatch.
Mark Gough reports.
The Metropolitan Police will release a new e-fit of a suspect in the disappearance of Madeleine McCann, reports claimed today.
It comes ahead of a fresh appeal on BBC's Crimewatch, due to be aired on Monday.
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Met Police assistant commissioner Mark Rowley said:
Gerry McCann says he is "encouraged" by new evidence relating to the disappearance of his daughter Madeleine.
"As parents, we won't accept Madeleine is dead until we see clear evidence that that is the case," he told ITV News.
"Clearly we're encouraged. There is new evidence, and the appeals will hopefully lead to further new evidence."
He said he and his wife were "optimistic that new pieces will be uncovered that will fill in parts of the jigsaw."
Dai Davies, a former commander at Scotland Yard, and now a security expert, says he welcomes the latest efforts to find missing Leicestershire schoolgirl Madeleine McCann.
For the first time, Scotland Yard is trawling through a vast log of mobile phone traffic identified in Portugal, at the time of her disappearance.
Latest ITV News reports
Latest appeal is the parents' best - and most likely their last - hope to find out through police work what happened to their daughter.
Kate and Gerry McCann will make an appeal on the BBC's Crimewatch programme after “fresh, substantive” material has been found.