The first Boeing 787 Dreamliner will take off from East Midlands Airport today heading for Florida.
The Dreamliner will leave at 11.40 for Sandford Airport
There has been a catalogue of Boeing 787 Dreamliner faults and groundings since the plane took to the skies.
In December, an United Airline Dreamliner made an emergency landing in New Orleans due to electrical problems.
In January 2013, a lithium ion battery pack sparked a fire on a Japan Airways Boeing 787.
Shortly, after all Dreamliners were grounded while safety checks were carried out, they were later cleared for service in April.
Boeing has carried out modification work and the Boeing 787 Dreamliner planes, seen as quiet and fuel-efficient, are flying again.
Thomson said that it was contacting customers due to travel on the Dreamliner between July 1 and 7 to tell them they would be travelling on Boeing 767 aircraft instead.
Following modification work, Boeing has now been given the go-ahead to operate the plane which was already years late going into service due to production difficulties.
Thomson, which is due to receive eight Dreamliners, is the UK launch customer for the plane and before the grounding had been busy promoting trips on the 787 which can seat between 210 and 290 passengers on medium-range routes.
The long wait for a UK airline to finally be able to operate Boeing's problem-hit new ultra-green Dreamliner plane will end on July 8.
On that date Thomson Airways will begin Boeing 787 Dreamliner services, using the aircraft to fly between Manchester and Orlando in Florida and between Glasgow and Cancun in Mexico. Some, but not all, 787's are powered by Derby-built Trent 1000 engines.
Thomson had to scrap all its planned Dreamliner flights for May and June 2013 after battery smoke emanating on two Dreamliner flights operated by Japanese carriers led to a grounding of the world's 787 fleet and a halt to deliveries.
A flypast by a new jet aircraft over the factory where its engines were made ended up being a bit of a damp squib.
Thousands of staff at Rolls-Royce stopped work to watch the display, only for low cloud to ruin the occasion