Derbyshire Police have confirmed that a 38-year-old man from Leicestershire collapsed while running the half marathon.
He was taken to the hospital but died later. His family have been informed and the coroner has been notified of the death.
The biggest half marathon in the Midlands will take place today in Birmingham, with 18,000 competitors expected to take part.
The Bupa Great Birmingham Run, which is now in its third year, attracts runners from both the UK and around the world.
The route starts at Paradise Circus before going out towards the village of Bournville and finishing back on Birmingham’s Broad Street.
Last year Kenyan runner Micah Kogo won a thrilling sprint for the line ahead of Ethiopian rival Abera Kuma, setting a new course record of one hour and 17 seconds.
This year's Bupa Great Birmingham Run officially launches today.
The 13.1 mile run will take place on October 21. Six-time Paralympic god medallist, David Weir, will be taking part along with around 18,000 other runners.
The half-marathon is the biggest in the Midlands, with runners taking in some of the city’s most iconic sights, including the Bullring, the Cadbury’s factor in Bourneville and Edgbaston Cricket Ground.
The family of a runner who died after the Great Birmingham Run hopes to run the same race next year in his memory.
Kevin Paterson was 36-years-old and an experienced runner, but he collapsed after crossing the finish line of the half marathon on October 21st.
There's a new course for runners to tackle in tomorrow's Nottingham Half Marathon.
Starting at 9.30am, runners will get a view of the castle, the Trent Bridge cricket ground and the Nottingham Forest Football Club as they continue the route, before finishing the final 400m along the new flood defence cycle track.