The Minister of State for International Development Alan Duncan has left the government.
Mr Duncan steps down after four years in the role.
Veteran minister and MP for Rushcliffe, Ken Clarke, has retired from the Government, sources close to him said.
He had already been demoted in the 2012 reshuffle, losing his post as justice secretary following a series of clashes with Home Secretary Theresa May.
Now the 74-year-old Nottinghamshire miner's son has quit as minister without portfolio, concluding a career which saw him hold government posts under four different Conservative prime ministers.
Rushcliffe MP Ken Clarke will take on the role of trade envoy after losing his job as Justice Secretary in the recent Cabinet reshuffle.
Mr Clarke will focus on selling British expertise in areas such as the NHS to emerging economies such as China.
Ken Clarke, the MP for Rushcliffe in Nottinghamshire, says Andrew Mitchell "highly regards" the police.
The Nottingham born MP Ken Clarke is expected to lose his Justice Secretary role but remain as a minister without portfolio as David Cameron reorders his Cabinet for the first time.
ITV News has more details.