It is not just local pride and the bragging rights that are at stake tonight, but also a place in the Premiership Final, as rivals Leicester Tigers and Northampton Saints square-up.
The Tigers welcome back six internationals for their trip to Franklin's Garden, including Niki Goneva.
Meanwhile, George Pisi and Samu Manoa will be among those re-joining the starting 15 for Saints.
Northampton will be hoping for revenge after Leicester beat them in the final last year, so tonight's match has all the ingredients for a cracker.
Richard Cockerill, Director of Rugby at Leicester Tigers, and player, Tom Croft, have been looking ahead to the encounter.
Leicester Tigers centre Vereniki Goneva has been named Player of the Year by supporters.Read the full story ›
Thanks for the retirement tweets. Tough decision, but right for a number of reasons. Looking forward to the next chapter! Whatever that is..
Leicester Tigers hooker George Chuter has announced he is retiring for professional rugby with immediate effect.
The 37-year-old was the first man to make 250 appearances in Premiership Rugby and was a Rugby World Cup finalist with England in 2007.
Chuter has been part of a Leicester squad which reached four European Cup Finals and has played seven Premiership Finals at Twickenham, a record he shares with former Tigers club captain Geordan Murphy.
He has played 292 first-team games in 13 seasons with Leicester Tigers.
"I’ve not really been able to sit back and reflect until now,” said the 37-year-old Chuter.
"To play nearly 300 games for Leicester and 100 for Saracens before that, plus 40 for England at various levels, gives me great pride."
Leicester Tigers star Lewis Moody is running the London Marathon this Sunday in aid of Crohn's and Colitis UK.
Moody made 223 appearances during his career at Welford Road and is now an ambassador for the charity.
Lewis said running the London marathon was something he always wanted to do:
"I am incredibly proud to be running in aid of such a great charity, which is very close to my heart as I am an Ulcerative Colitis sufferer".
Leicester Tigers have beaten Gloucester today in the Aviva Premiership.
The final score was 11-8 to the Tigers.
Worcester Warriors face Leicester Tigers tonight in the Premiership in one of their toughest games of the season.
They are still looking for their first Premiership win, and tonight they face the champions. But Director of Rugby, Dean Ryan, and player, James Percival, still believe they can defeat Leicester.
Leicester Tigers Head Coach Richard Cockerill has confirmed that Fly-Half Toby Flood will leave the club at the end of the season.
For more on this story, visit ITV Sport.
The news comes as the club announced record season ticket numbers, with almost 15,000 fans pledging their support to the club for the rest of the year.
The Tigers already have more than 7,500 supporters signed up for season tickets next season, and have an all-time high average attendance this year, with more than 21,600 fans at each game on average.