A timeline of some of the key events since Madeleine McCann disappeared in 2007 following reports suspects have been identified.
The parents of Madeleine McCann have admitted it was "difficult" to allow their twins to enjoy the same freedom as other children.
Our correspondent Gareth Owen has revisited Praia da Luz, five years since the disappearance of Madeleine McCann.
Reports say British police looking into the disappearance of Madeleine McCann believe her kidnapper was staying in a holiday flat near the family.
The Sunday Mirror says Scotland Yard detectives have narrowed their search of the youngster, from Rotheley in Leicestershire, to four apartment blocks where the family were on holiday.
Our investigative review is ongoing and we are encouraged by the progress we are making. We are reviewing a significant number of documents and continue to identify potential lines of inquiry.
We can confirm that as part of this process we have identified a number of persons of interest, but any suggestion that the MPS is asking the Portuguese Police to make arrests in connection with this inquiry is entirely inaccurate.
– A Metropolitan Police spokesman
We are in regular contact with Kate and Gerry McCann and they are kept fully updated on the progress of our work.
We also continue to work closely with the Portuguese Police and are actively considering our next steps.
The parents of Madeleine McCann say hopes of finding her have been reinforced by the recent discovery of Amanda Berry, Gina DeJesus and Michelle Knight in Ohio, a decade after they went missing in separate incidents.
When the women were found, the McCanns said the rescue of the women "reaffirmed" their hope of finding their daughter, which had never diminished.
– Statement from the parents of Madeleine McCann
Their recovery is also further evidence that children are sometimes abducted and kept for long periods.
So we ask the public to remain vigilant in the ongoing search for Madeleine.
Clarence Mitchell, spokesman for the Kate and Gerry McCann, said: "Kate and Gerry remain very, very pleased with the work that Scotland Yard are doing and have been encouraged by Operation Grange from the day it began.
"Beyond that, they simply will not comment on what are police operational matters."
Detective Chief Superintendent Hamish Campbell, who led a Metropolitan Police review of the six-year-old case, retired today as head of Scotland Yard’s homicide and serious crime command.
Speaking earlier this month, on the sixth anniversary of Madeleine McCann's disappearance, her parents Kate and Gerry, said they had not given up hope of finding their daughter.
Speaking on Daybreak, the couple said they have not lost hope that their daughter would be found and continue to campaign tirelessly for information on her whereabouts.
They believe the involvement of the Metropolitan Police now meant the hunt for their daughter was escalating, rather than grinding to a halt.
Mrs McCann said: "The search is very much ongoing. Nothing is slowing down, if anything I feel it's escalating with the work of the Met.
"And again it's just be vigilant, please still take your posters on holiday and don't forget about her, she's still missing.
"We haven't lost hope, our hope isn't any less than it was after the first 24, 48 hours."
Detectives reviewing the disappearance of Madeleine McCann have identified at least "a handful of people of interest" in connection with the case, Scotland Yard has confirmed.
– Detective Chief Superintendent Hamish Campbell
The purpose of the review was to look at the case with fresh eyes and there is always real benefit in doing so. The review has further identified both investigative and forensic opportunities to support the Portuguese.
There is more than a handful of people of interest which could be explored further if only to be eliminated.
The key things are to investigate the case and our work is happening to support the Portuguese.
A number of new potential suspects in the Madeleine McCann disappearance case have been identified, the London Evening Standard reports.
Scotland Yard investigators told the newspaper there are people "of interest" to the inquiry, after they carried out a review of the case.
Detective Chief Superintendent Hamish Campbell, who heads Scotland Yard's Homicide and Serious Crime Command, said a "good number" of individuals should be questioned and urged Portuguese police to investigate the new leads.
Madeleine went missing from an apartment in Praia de Luz, Portugal, in 2007 while her parents Kate and Gerry McCann were in a restaurant nearby.
There are reports that new suspects have been identified in the hunt for the missing girl Madeleine McCann.
More to follow.
Today is the 10th birthday of Madeleine McCann, the little girl who went missing on a family holiday to Portugal.
Speaking to ITV's Daybreak programme on the anniversary of Madeleine's disappearace, her parents urged the public to continue taking posters of their daughter on foreign holidays and not to give up hope of finding her.