The Portuguese inquiry into the disappearance of Madeleine McCann has been reopened amid new leads in the case.
Six years on from her disappearance, Portuguese police are set to re-open the case into missing Leicestershire girl Madeleine McCann.
Detectives have ruled out the key sighting that underpinned the original Madeleine McCann investigation and adopted a new focus in the hunt.
Portuguese investigation will run in parallel with Met's Operation Grange #McCann
AC Rowley: "This is a welcome development but both investigations at relatively early stages, with much work remaining to be done" #McCann
The Portuguese attorney general has said new leads mean the formal investigation into Madeleine McCann's disappearance needs to be reopened.
The Home Secretary said she welcomed the news that Portuguese police would re-open the case in to the disappearance of Madeleine McCann.
Theresa May said: "I welcome the developments that have taken place and the work the Metropolitan Police are doing with the Portuguese police on this case. I hope that what we're going to see is a resolution to this case for the sake of Maddie's parents and family."
The parents of Madeleine McCann believe it would be an "important step forward" if Portuguese police reopened the investigation into the disappearance of their daughter.
A spokesman for the couple told the Daily Mirror: “Kate and Gerry don’t want to get their hopes up too much. But if the Portuguese do resume their investigation it would be a significant development and an important step forward.”
Earlier this month, detectives searching for Madeleine McCann ruled out the key sighting that underpinned the original Portuguese investigation and released e-fit images of a different man they wish to speak to who was seen carrying a child on the night she went missing.
Thousands of calls have been made to police in both the UK and across Europe following the recent appeal.
ITV News understands Portuguese police may be about to re-open the investigation into the disappearance of Madeleine McCann.
It is understood a review team, created in March 2012 and involving 37 Portuguese officers, have found two or three new details, which warrant further investigation.
Portuguese police are yet to confirm or deny the reports. Kate and Gerry McCann have always said they would welcome the formal re-opening of the investigation in Portugal.
It would have been "very difficult" for officers in Praia da Luz, Portugal, to know whether they were dealing with a serious crime immediately after the disappearance of Madeleine McCann, the country's most senior police officer has said.
Metropolitan Police Commissioner Sir Bernard Hogan-Howe has defended the way Portuguese police handled the initial investigation after the Leicestershire girl vanished.
Speaking on LBC 97.3, he said: "I think sometimes these things at the beginning can be very difficult to deal with, you don't know exactly if the child has just wandered off. It can be very difficult to know if you've got a very serious crime.”
"I'm sure for them that must have been a challenge. Anybody can go back after two, three, five, six years and say 'why didn't you do that'?”
"That's easy in hindsight.”
"We don't like it when it happens to the Met, and I am certainly not going to do it to the Portuguese. What I'm determined to do is to work together to make sure we have got the best chance to now try to get to the bottom of this terrible tragedy.”
"There is a poor family there who've got the torture of not knowing whether their daughter is alive or not."
A further appeal is due to air on Irish television later this month.
Detectives investigating the disappearance of Madeleine McCann say they have received more than 2,400 calls since programmes launching a new appeal were aired across Europe.
Scotland Yard officers launched a renewed case on Crimewatch earlier this week before travelling to both Holland and Germany along with Madeleine's parents Kate and Gerry McCann.
New e-fits were shown of people they wish to speak to in relation to the disappearance in 2007.
Detectives investigating the disappearance of Madeleine McCann have received another 150 calls after a fresh appeal for information was aired on Dutch television.
An appeal was broadcast last night in The Netherlands on a programme called Opsporing Verzocht, and will feature on the German programme Aktenzeichen XY...ungelost tonight.
British police have already received hundreds of calls and emails after a refreshed appeal was aired on the BBC's Crimewatch on Monday night.
Scotland Yard said yesterday they had received more than 730 calls and 212 emails after the broadcast, and Madeleine's parents Kate and Gerry McCann said they are "genuinely hopeful" that a breakthrough could be possible.
The latest appeal for information about the disappearance of Madeleine McCann will be shown on German television tonight.
It will include the new e-fit images of two men spotted near the scene of her disappearance, who detectives believe may be German.
Television station ZDF will show a reconstruction of the events on the night in May 2007 when Madeleine went missing in Praia da Luz in Portugal.
It will be aired on the 'Aktenzeichen XY - Ungeloest' show, which is translated as "File XY - Unsolved". It was also include an appeal from parents Kate and Gerry McCann.