Northampton Saints: Foden; K Pisi, G Pisi, Burrell, north; Myler, L Dickson; A Waller, Haywood, Ma'afu; Dickinson, Day; Clark, Wood (capt), Manoa
Replacements: McMillan, Corbisiero, Denman, Nutley, Dowson, Fotuali'i, Wilson, Stephenson
Harlequins: Brown; Yarde, Hopper, Lowe, Monye; Swiel, Care; Lambert, Ward, Collier; Matthews, Robson; Trayfoot, Clifford, Easter (capt)
Replacements: Gray, Marfo, Sinckler, Twomey, J Chisholm, Dickson, Casson, R Chisholm
Northampton Saints fans are in high spirits ahead of the game against Harlequins, at Twickenham, which starts at 4.30pm.
Wasps are hoping to break the attendance record for a regular Premiership Rugby fixture as they prepare to play their first home game at the Ricoh Arena in Coventry.
More than 27,000 people are expected for Sunday's game against London Irish.
An independent committee will hear a misconduct complaint filed by Leicester Tigers against former player Martin Castrogiovanni.
The prop, who now plays for French side Toulon, is alleged to have made disparaging comments to the media following their Champions Cup defeat to Tigers earlier this month.
Northampton Saints have been drawn in Pool 5 for the European Rugby Champions Cup.
They'll play Racing Metro, Ospreys and Treviso. Last season's beaten finalists Saracens will tae on Munster, Sale Sharks and Clermont Auvergne.
Local rivals Leicester Tigers have been drawn with Scarlets, Ulster and reigning champions Toulon.
Leicester Tigers Head Coach Richard Cockerill has confirmed that Fly-Half Toby Flood will leave the club at the end of the season.
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The news comes as the club announced record season ticket numbers, with almost 15,000 fans pledging their support to the club for the rest of the year.
The Tigers already have more than 7,500 supporters signed up for season tickets next season, and have an all-time high average attendance this year, with more than 21,600 fans at each game on average.
The Rugy Football Union has published its judgement on Leicester Tigers' manager Richard Cockerill's ban.
The judgement said that at first there was "nothing untoward" but in the second occasion Cockerill's behaviour was regarded as "obscene, inappropriate and unprofessional".
It said his words could have been "construed as intimidation" as well as listing "various threats to instruct his players at half time to 'smash'" the opposing team. It said: