Workers at Remploy are to stage two 24-hour strikes.
It is after the firm, based in Leicester, announced it is planning to close 36 of its 54 sites, because of government funding cuts.
The plans put at risk the jobs of more than 1,500 disabled workers.
A spokesperson for the Department of Work and Pensions said, "We're disappointed to hear that the unions are proposing to take strike action which will do nothing to secure the future jobs of Remploy staff.
"The Government would encourage the trade unions to fully engage with Remploy during the consultation process to provide the best possible support and success for disabled staff who may leave the company."