They serve more than four million people across the region, and now two of those people have said a very special thank-you to East Midlands Ambulance Service for their life-saving skills.
Simon Bakewell from Leicester suffered a heart attack while out walking with his family, just weeks after having a heart transplant. His heart stopped beating - but an off-duty crew managed to help bring him back to life. Callum Watkinson reports.
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Some outbreaks of rain. Windy on Wednesday. Colder by weekend.
Rather cloudy with patchy rain, brighter at times on Wednesday.
21 people died after bombs exploded in two Birmingham pubs in November 1974. Can you help us tell their story?