They serve more than four million people across the region, and now two of those people have said a very special thank-you to East Midlands Ambulance Service for their life-saving skills.
Simon Bakewell from Leicester suffered a heart attack while out walking with his family, just weeks after having a heart transplant. His heart stopped beating - but an off-duty crew managed to help bring him back to life. Callum Watkinson reports.
More top news
A coach carrying schoolchildren has collided with a van in Warwickshire.
A brave ten-year-old has shaved off all her hair in front of her classmates to raise money for the hospice which cared for her dying dad.
Company bosses have confirmed that more than 300 workers will lose their jobs at the Goodyear factory in Wolverhampton.