Bloor Homes want to buy land near to Anne Hathaway's Cottage in Shottery to build new homes.
The Communities Secretary Eric Pickle gave the deal the go-ahead but the County Council has said that it is against it.
The trust knows it can't rule out being forced to sell the land at some point.
Peter Kyle is the Chairman of the Shakespeare Birthplace Trust.
More top news
A man is injured tonight after the car he was driving crashed with a lorry in Warwickshire.
West Midlands Police has paid out £5 million to telecom companies after using 'snooping powers' to look at mobile phone records of suspects.
The daughter of a woman killed when a double-decker bus crashed into a Sainsbury's has told ITV News she will be "sadly missed by all".