The Big Issue has confirmed both stabbing victims were sellers of the publication.
In a statement, founder and Editor-in-Chief John Bird says he and his staff are deeply saddened.
"Myself and everyone at The Big Issue has been deeply saddened to hear the tragic news that two of our well-liked Birmingham based vendors were stabbed to death in the city centre yesterday evening.
"We are struggling to make any sense of this utterly senseless attack, and our sincerest condolences go out to the families of the victims.
"This awful crime, perpetrated against two hard working, mild mannered men, only serves to illustrate the extreme vulnerability of people who live and work on the streets. Which is why we at the Big Issue are constantly striving to create opportunities which will help our vendors to get off the streets and out of harms way.
"We are truly devastated that these two individuals have been deprived of just such a future."
More top news
Foster families in Wolverhampton who can commit to homing sibling groups are set to receive more financial help from the city council.
The RMT Union called a day of action in a dispute with Cross Country over Sunday working patterns for senior staff.
32-year-old Darren Cumberbatch was detained by police following an incident in Nuneaton in July and later died in hospital.