The emergency services were called to a house fire overnight on Holtlands Drive in Alvaston.
The fire service received the call just after 2:30 this morning.
One man was taken to hospital where he later died. All the other people in the house were accounted for.
Firefighters left the scene just before 6.00 but will return later today to carry out further investigations.
More top news
Police are investigating after a passenger on a packed plane from Birmingham allegedly started two fires in mid-air.
The Sky Bet League One manager of the month award for August has been won by Walsall boss Dean Smith.
Images have been released after two bothers were threatened before having their bikes stolen.