The emergency services were called to a house fire overnight on Holtlands Drive in Alvaston.
The fire service received the call just after 2:30 this morning.
One man was taken to hospital where he later died. All the other people in the house were accounted for.
Firefighters left the scene just before 6.00 but will return later today to carry out further investigations.
More top news
Its the UK's biggest ever gang injunction for members of the Burger Bar Boys and Johnson Crew in Birmingham.
The shops owners say they feel "disheartened" after it was broken into for the second time in four years.
Several people, who the police believe to be victims, were found at a house in Derby.