The emergency services were called to a house fire overnight on Holtlands Drive in Alvaston.
The fire service received the call just after 2:30 this morning.
One man was taken to hospital where he later died. All the other people in the house were accounted for.
Firefighters left the scene just before 6.00 but will return later today to carry out further investigations.
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Outbreaks of rain first thing in the east will ease through the morning, but remaining largely cloudy throughout the rest of the day.
Another cloudy day with outbreaks rain or drizzle and mist in the morning. Some heavier bursts of rain possible at first.
Another cloudy day ahead with outbreaks rain or drizzle and mist in the morning.