The emergency services were called to a house fire overnight on Holtlands Drive in Alvaston.
The fire service received the call just after 2:30 this morning.
One man was taken to hospital where he later died. All the other people in the house were accounted for.
More top news
Marches to protest against extremism and terrorism were held in Birmingham city centre today.
After a cloudy and damp evening, the cloud should clear through the early hours of tomorrow.
It will be mainly cloudy with some outbreaks of mostly light rain and drizzle.