Special administrators will be running the Mid Staffordshire NHS Foundation Trust from today.
It is the first foundation trust in the country to be put into administration.
It means that regulators will draw up a "sustainable" action plan for its future.
Hundreds of patients died needlessly at Stafford Hospital when financial targets were put before patient care.
The Francis Report highlighted the "appalling and unnecessary suffering of hundreds of people" between 2005 and 2009.
What does the decision to appoint trust special administrators to run Mid Staffordshire NHS Foundation Trust mean?
The Health Secretary's response came after failings at Mid Staffordshire NHS Trust, which highlighted the suffering of hundreds of people.
The Health Secretary, Jeremy Hunt, has today outlined new plans for NHS following the Stafford scadal