Gary Barlow, Chris Evans, James May and Brian Cox will drive through the Midlands today in a pink Rolls Royce raising money for Breast Cancer Care.
The challenge will see them driving from Land's End to John O'Groats in a bespoke pink Rolls Royce Ghost.
They want to try and raise £1 million in 24 hours.
The four celebrities will stop off in Birmingham as part of their trip to meet breast cancer sufferers from the Midlands.
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Many of the items up for grabs at the Royal Shakespeare Company in Stratford-upon-Avon were handmade for famous actors.
A precious bracelet lost by a grandmother has been found by workers at the Grantham Household Waste Recycling Centre.
Two men from the Midlands have been charged under Section 1 of The Modern Slavery Act.