Gary Barlow, Chris Evans, James May and Brian Cox will drive through the Midlands today in a pink Rolls Royce raising money for Breast Cancer Care.
The challenge will see them driving from Land's End to John O'Groats in a bespoke pink Rolls Royce Ghost.
They want to try and raise £1 million in 24 hours.
The four celebrities will stop off in Birmingham as part of their trip to meet breast cancer sufferers from the Midlands.
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West Midlands weather: Wet and windy tonight
East Midlands weather: Fine tonight, wet tomorrow
This weekend we will lose an hour of unsettled weather when the clocks go forward on Sunday.