The march has been organised by a community group, with the support of local MPs and Stafford Borough Council.
It comes after the hospital has been placed in administration.
The rally is aimed at saving services such as the Accident and Emergency department, intensive care and maternity units.
More top news
A 49-year-old man is in hospital after suffering a serious head injury during a fight.
The missing 15-year-old boy was last seen on Monday 12 June close to a train station.
The 26-year-old had been spending the evening out with friends.