The new aircraft, known as 13 Squadron, which were officially "stood up" in October, started flying missions over Afghanistan this week from their base in Lincolnshire.
The hi-tech Reaper drones are primarily used to gather intelligence on enemy activity on the ground, but they also carry 500lb bombs and Hellfire missiles for precision strikes on insurgents.
An MoD spokesman said they had been carrying out missions including intelligence, surveillance and reconnaissance, but would not comment on exactly what individual missions had been flown in the past week by drones piloted from the UK.
More top news
Police say they're increasing concerned for 12-year-old Shane Pinder who went missing after he finished school in Birmingham on Friday.
There’s major disruption across the Midlands with both runways at the region’s main airports disrupted because of high winds & snow drifts.
Heavy snow overnight has resulted in Derby County cancelling its Championship game against Cardiff