Emergency services were called at around 8.10am this morning to reports of a fire involving a neon sign.
Greater Manchester Fire and Rescue Service say they received a number of calls from members of the public as the smoke could be seen from city centre apartment blocks.
Firefighters have broken into a neighbouring property to try and stop the fire spreading and are tackling the blaze from the ground and an aerial appliance as it has consumed the ground, first and second floors of the building.
Crews from Stretford, Hyde and Salford have been called to tackle the incident and have found it began in the ground floor of a commercial property.
The fire has caused a build up of traffic in the area and police are at the scene to manage that situation.
Police have now closed Chester Road, between Bridgewater Way and Mancunian Way, while emergency services deal with the blaze.