Twenty protesters were blockading a drilling rig in Chesterfield today, they said.
The demonstrators from anti-fracking group, Frack Off, were blockading Cuadrilla Resource's drilling rig at the site in Derbyshire.
Fracking is the controversial extraction of gas from shale rock.
The group said four activists had locked themselves to the site's gate in a bid to prevent the rig from moving to its frack site in Lancashire.
Demonstrator Elsie Walker, 27, said: "The scale of development proposed is being completely ignored.
"Cuadrilla wants to drill 800 wells in Lancashire alone.
"They are one company going after one type of gas.
"There are several companies going after several types of unconventional gas in the UK and all potentially on a similar scale to Cuadrilla.
"If this goes ahead, we will witness the total industrialisation of the British countryside and the destruction of the land and water on which we depend.
"We cannot allow this to happen."
In a statement, Derbyshire Police said: "Police officers are monitoring a group of protesters who are demonstrating outside a drilling company on Old Pit Lane in Danesmoor, near Chesterfield.
"Officers were called at 5.20 this morning by staff at the firm.
"This is a peaceful protest which is not blocking access to other premises.
"Officers are talking to the protesters and will remain at the scene until the protest is over."