Successes on day one will no doubt be a huge boost for ParalympicsGB, especially those athletes from our region.
Manchester provided two Gold medals yesterday (August 30) - Sarah Storey stormed to victory in the Velodrome and Jonathan Fox broke a world record, taking top spot in the 100m Backstroke.
Today (August 31), Helen Frederiksen from Merseyside and Stockport's Natalie Massey will look to emulate their teammate.
Frederiksen won Silver in the 400m freestyle in Beijing, today she's looking to go one better.
Also look out for Matt Walker MBE from Stockport - a seasoned Paralympian going in the 50m butterfly who's in good form.
Out of the pool, Liverpool's Judo brothers Dan and Marc Powell are looking to follow in their father's footsteps by winning their first Paralympic medals.
Terry Powell won Bronze at both Seoul and Atlanta. He'll be there watching proudly today.
Elsewhere Rik Waddon is aiming to make the final of the Men's Individual C3 Pursuit this afternoon and Dave Clarke from Wigan makes his 140th international appearance when Great Britain's 5-a-side team start their campaign against Spain.